C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/46 (2006.01) A61K 31/425 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61P 25/28 (2006.01) C07D 277/54 (2006.01) C07D 277/56 (2006.01) C07D 277/60 (2006.01) C07D 277/82 (2006.01) C07D 417/04 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2501803
The invention provides compounds of Formula (I): wherein R1, R2, R3, R4, R6, R7, and A are as defined. Compounds of Formula (I) have activity inhibiting production of A.szlig.-peptide. The invention also provides pharmaceutical compositions and methods for treating diseases, for example Alzheimer's disease, in mammals comprising compounds of Formula (I).
La présente invention concerne des composés représentés par la formule (I) dans laquelle R', R2, R3, R4, R6, R' et A sont tels que définis dans le descriptif. Les composés représentés par la formule (I) présentent une activité d'inhibition de la production du peptide A.szlig.. La présente invention concerne également des compositions pharmaceutiques et des méthodes de traitement de maladies, telles que par exemple la maladie d'Alzheimer, chez des mammifères, qui comprennent des composés de formule (I). Formule (I)
Chen Yuhpyng Liang
Corman Michael Leon
Pfizer Products Inc.
Smart & Biggar
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