C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/10 (2006.01) A61K 31/5355 (2006.01) A61P 3/00 (2006.01) C07D 417/10 (2006.01)
Patent
CA 2744946
This invention relates to novel compounds of the Formula Formulas (I), (Ia1- 20) (Ib1-20) (Ic1-20), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11.beta.-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.
La présente invention porte sur de nouveaux composés représentés par les formules (I), (Ia1-20), (Ib1-20), (Ic1-20), sur des sels pharmaceutiquement acceptables de ceux-ci et sur des compositions pharmaceutiques de ceux-ci, qui sont utiles pour le traitement thérapeutique de maladies associées à la modulation ou l'inhibition de la 11ß-HSD1 chez des mammifères. L'invention porte en outre sur des compositions pharmaceutiques des nouveaux composés et sur des procédés permettant de les utiliser pour la réduction ou l'ajustement de la production de cortisol dans une cellule ou l'inhibition de la conversion de cortisone en cortisol dans une cellule.
Eckhardt Matthias
Himmelsbach Frank
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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