Flt-4 (fms-like tyrosine kinase), flt-15, variants thereof...

Details Flt-4 (fms-like tyrosine kinase), flt-15, variants thereof... Flt-4 (fms-like tyrosine kinase), flt-15, variants thereof...

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 14/71 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2191071

Disclosed is an altered, soluble form of the FLT polypeptide being capable of binding to VEGF and thereby exerting an inhibitory effect thereon, the polypeptide comprising five or fewer complete immunoglobulin-like domains, together with pharmaceutical compositions comprising the polypeptide, and various uses thereof.

On décrit une forme soluble modifiée du polypeptide du récepteur de la tyrosine kinase (FLT), capable de se lier au facteur de croissance de cellules endothéliales vasculaires (VEGF) et d'exercer ainsi un effet inhibiteur sur celui-ci, ce polypeptide comprenant au maximum cinq domaines complets de type immunoglobuline. On décrit également les compositions pharmaceutiques comprenant ce polypeptide ainsi que diverses utilisations de celui-ci.

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