Indole and indoline cyclopropyl amide derivatives as ep4...

Details Indole and indoline cyclopropyl amide derivatives as ep4... Indole and indoline cyclopropyl amide derivatives as ep4...

C - Chemistry, Metallurgy

07

D

C07D 209/08 (2006.01) A61K 31/404 (2006.01) A61K 31/41 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2679175

The invention is directed to indole and indoline cyclopropyl amide derivatives as EP4 receptor antagonists useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoid arthritis and cancer. Pharmaceutical compositions and methods of use are also included.

L'invention porte sur des dérivés d'indole et indoline cyclopropyl amide comme antagonistes du récepteur EP4, utiles pour le traitement de maladies ou conditions à médiation par EP4, telles que la douleur aiguë et chronique, l'ostéoarthrite, l'arthrite rhumatoïde et le cancer. L'invention porte également sur des compositions pharmaceutiques et des procédés d'utilisation.

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