Pyrrole substituted 2-indolinone protein kinase inhibitors

Details Pyrrole substituted 2-indolinone protein kinase inhibitors Pyrrole substituted 2-indolinone protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/535 (2006.01) A61K 31/5377 (2006.01) C07D 209/04 (2006.01) C07D 209/34 (2006.01) C07D 413/06 (2006.01)

Patent

CA 2314156

The present invention relates to novel pyrrole substituted 2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

La présente invention concerne de nouveaux composés 2-indolinone à substitution pyrrole, ainsi que les sels physiologiquement acceptables et les promédicaments de ceux-ci. Ces nouveaux composés, destinés à moduler l'activité de la protéine kinase, sont donc utiles pour prévenir et traiter les dysfonctionnements cellulaires liés à la protéine kinase, par exemple le cancer.

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