Insertion of furin protease cleavage sites in membrane...

Details Insertion of furin protease cleavage sites in membrane... Insertion of furin protease cleavage sites in membrane...

C - Chemistry, Metallurgy

12

P

C12P 21/06 (2006.01)

Patent

CA 2520604

Cleavage site for the protease furin is inserted between domains of a membrane glycoprotein. Upon cleavage by furin in the trans~-Golgi network, the protein is separated into individual membrane-free domain that retains its native conformation. This protocol can be used to produce virus membrane protein domains for structural analysis and for trials as vaccines.

Insertion d'un site de clivage de la furine protéase entre des domaines d'une glycoprotéine de membrane. Au moment du clivage par la furine dans le réseau de trans-Golgi, la protéine est séparée en domaines exempts de membrane conservant sa conformation d'origine. On peut utiliser ce protocole afin de produire des domaines de protéine de membrane de virus dans le but d'effectuer une analyse structurale ou des essais permettant d'obtenir des vaccins.

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