Immunomodulatory molecules and process for producing the same

Details Immunomodulatory molecules and process for producing the same Immunomodulatory molecules and process for producing the same

C - Chemistry, Metallurgy

07

K

C07K 14/725 (2006.01) A61K 38/10 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 16/28 (2006.01) G01N 33/543 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2285571

The present invention is directed to an immunoregulatory molecule that regulates costimulatory signal transduction through interaction with the molecules involved in costimulatory signal transduction present on antigen presenting cells and/or T cells in the activation of T cells by antigen presenting cells and a process for preparing the same. Said immunoregulatory molecule comprises a peptide which has two cysteine (Cys) residues forming Cys-Cys linkage and comprises at least six amino acid residues between said Cys-Cys linkage. Said immunoregulatory molecule is obtained by screening a phage random peptide library with a monoclonal antibody to CTLA--4 on T cells involved in costimulatory signal transduction.

L'invention concerne des molécules immunomodulatrices qui subissent, lors de l'activation des lymphocytes T par des cellules présentant l'antigène, une interaction mutuelle avec des molécules, en liaison avec la conduction des signaux impulsionnels auxiliaires sur les cellules présentant l'antigène et/ou les lymphocytes T, pour ainsi réguler la conduction des signaux impulsionnels auxiliaires. Ces molécules présentent chacune un peptide comportant deux restes cystéine (Cys) formant une liaison Cys-Cys et présentant une séquence comprenant au moins six acides aminés dans la liaison Cys-Cys. Ces molécules peuvent être obtenues par criblage d'une bibliothèque de peptides aléatoires phagiques, au moyen d'un anticorps monoclonal contre CTLA-4 sur les lymphocytes T, en liaison avec la conduction des signaux impulsionnels auxiliaires.

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