Methods and reagents for treatment and diagnosis of vascular...

Details Methods and reagents for treatment and diagnosis of vascular... Methods and reagents for treatment and diagnosis of vascular...

Category

A - Human Necessities

Subcategory

61

Subsubcategory

K

IPC codes

A61K 39/395 (2006.01) A61K 31/7105 (2006.01) A61K 38/17 (2006.01) C12Q 1/68 (2006.01) G01N 33/483 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) C07K 14/47 (2006.01)

Type

Patent

Patent number

CA 2659392

Description

Disclosed are screening methods for determining a human subject's propensity to develop a vascular disorder and/or age-related macular degeneration (AMD), therapeutic or prophylactic compounds for treating disease or inhibiting its development, and methods of treating patients to alleviate symptoms of the disease, prevent or delay its onset, or inhibit its progression. The inventions are based on the discovery that persons with a genome having a deletion of the CFHR-1 and/or CFHR-3 gene, which normally lie on human chromosome 1 between DNA encoding CFH and CFHR-4, are at reduced risk of developing AMD, and elevated risk of developing vascular disease such as aneurysm.

L'invention concerne des procédés de criblage pour déterminer la propension d'un sujet humain à développer un trouble vasculaire et/ou une dégénérescence maculaire liée à l'âge (AMD), des composés thérapeutiques ou prophylactiques pour traiter une maladie ou inhiber son développement, et des procédés pour traiter des patients pour soulager des symptômes de la maladie, empêcher ou retarder son début, ou inhiber sa progression. Les inventions sont basées sur la découverte que des personnes avec un génome ayant une délétion du gène CFHR-1 et/ou CFHR-3, qui se trouvent normalement sur le chromosome humain 1 entre l'ADN codant pour CFH et CFHR-4, sont à risque réduit de développer une AMD, et à risque élevé de développer une maladie vasculaire telle qu'un anévrisme.

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