C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2507400
The present invention relates to compositions comprising DNA attached to an immunostimulatory oligonucleotide (CpG) via a locked nucleic acid oligonucleotide of a defined sequence. In particular the present invention provides compositions comprising a plasmid containing a gene encoding a protein of interest, wherein said plasmid may be introduced to a tissue or cell and the gene expressed, complexed to the LNA -CpG. Also provided is a method of co-synthesis of CpG and LNA to form compositions for use as adjuvants with DNA plasmid vaccines.
L'invention concerne de nouvelles compositions comprenant de l'ADN fixé sur un oligonucléotide immunostimulant (CpG) par le biais d'un oligonucléotide à acide nucléique bloqué d'une séquence définie. L'invention concerne notamment des compositions comprenant un plasmide contenant un gène codant une protéine d'intérêt, ledit plasmide pouvant être introduit dans un tissu ou dans une cellule, le gène étant exprimé et complexé en LNA-CpG. L'invention concerne par ailleurs un procédé de co-synthèse de CpG et de LNA, afin de former des compositions s'utilisant comme adjuvants avec des vaccins plasmide d'ADN.
Glaxo Group Limited
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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