Process for the preparation of n-(substituted...

Details Process for the preparation of n-(substituted... Process for the preparation of n-(substituted...

C - Chemistry, Metallurgy

07

C

C07C 317/46 (2006.01) C07C 231/08 (2006.01) C07C 253/30 (2006.01) C07C 255/66 (2006.01) C07C 315/02 (2006.01) C07C 319/14 (2006.01) C07C 323/62 (2006.01) C07D 301/16 (2006.01) C07D 303/48 (2006.01) C07C 255/60 (2006.01) C07C 323/60 (2006.01)

Patent

CA 2423158

The present invention provides an improved process for the preparation of N- (substituted phenyl)-3-alkyl-, aryl- and heteroarylsulfonyl-2-hydroxy-2-alkyl- and haloalkylpropanamide compounds of formula I (I), The formula I compounds exhibit antiandrogenic activity and are useful in the treatment of malignant or benign prostatic disease or of androgen dependent disease conditions such as acne, hirsutism or seborrhoea.

L'invention concerne un procédé amélioré de préparation de composés N-(phényle substitué)-3-alkyle-, aryle- et hétéroarylsulfonyle-2-hydroxy-2-alkyle- et haloalkylpropanamide représentés par la formule (I). Les composés de cette formule I font preuve d'une activité antiandrogénique et sont utiles dans le traitement de maladies prostatiques bénignes ou malignes, ou dans le traitement d'états pathologiques dépendant des androgènes tels que l'acné, l'hirsutisme ou la séborrhée.

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