Use of mullerian inhibiting substance for treating excess...

A - Human Necessities – 61 – K

Patent

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A61K 38/16 (2006.01) A61K 38/22 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2384991

The present invention provides a method of treating a condition or disease characterized by an excess of one or more androgens, the method comprising administering an effective amount of MIS protein or nucleic acid encoding MIS to a patient. The present invention also provides a method of decreasing the level of one or more androgens to a level below the normal level, the method comprising administering an effective amount of MIS protein or nucleic acid encoding MIS to a patient. The methods of the present invention are particularly well-suited for the treatment of prostatic cancer, polycystic ovarian disease, benign prostatic hypertrophy, and precocious puberty.

La présente invention concerne une méthode de traitement d'un état pathologique ou d'une maladie caractérisé par un excès de un ou plusieurs androgènes. Cette méthode consiste à administrer à un patient une dose efficace d'une protéine d'inhibition des canaux de Müller (MIS) ou d'un acide nucléique codant pour ladite protéine MIS. La présente invention concerne également une méthode permettant de faire passer le niveau d'un ou de plusieurs androgènes en deçà du niveau normal, ladite méthode consistant à administrer à un patient une dose efficace d'une protéine MIS ou d'un acide nucléique codant pour ladite protéine MIS. Les méthodes selon la présente invention sont particulièrement indiquées pour le traitement du cancer de la prostate, des ovaires polykystiques, de l'hypertrophie bénigne de la prostate, et de la puberté précoce.

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