N-arylheteroarylalkyl 1-phenyl-imidazol-2-one compounds for...

Details N-arylheteroarylalkyl 1-phenyl-imidazol-2-one compounds for... N-arylheteroarylalkyl 1-phenyl-imidazol-2-one compounds for...

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/44 (2006.01) C07D 401/06 (2006.01) C07D 401/10 (2006.01)

Patent

CA 2143193

A class of N-arylheteroarylalkyl 1-phenyl-imidazol-2-one compounds is described for use in treatment of circulatory disor- ders such as hypertension and congestive heart failure. Compounds of particular interest are angiotensin II antagonists of formu- la (I) wherein A is selected from (a), (b), (c), (d), (e) and (f); wherein m is one; wherein each of R1, R2 and R3 is independently selected from hybrido, alkyl, alkoxy, cyano, halo, hydroxy, carboxyl, alkoxycarbonyl, formyl and acetyl; alkylcarbonyl and haloalkylcarbonyl; wherein R4 is hybrido; wherein R5 is alkyl; wherein R6 is an acidic group selected from COOH and (g); or a stereoisomer or a tautomer thereof or a pharmaceutically-acceptable salt.

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