Methods for treating kidney disorders with pax2

Details Methods for treating kidney disorders with pax2 Methods for treating kidney disorders with pax2

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 33/00 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 38/30 (2006.01) A61P 13/12 (2006.01)

Patent

CA 2398310

The present invention relates to a method for treating, delaying and/or preventing renal dysfunction/failure in a mammal comprising administering a therapeutically effective amount of a substance capable of inducing and/or enhancing Pax2 expression. Furthermore, the invention relates to the use of an effective dose of a substance capable of inducing and/or enhancing Pax2 expression in a mammal for the preparation of a pharmaceutical composition for treating, preventing or delaying a renal dysfunction/failure in a mammal. Additionally, the present invention provides for a method for converting mesenchymal tissue into an epithelial tissue comprising the administration of an effective amount of a substance capable of inducing and/or enhancing Pax2 expression in said mesenchym and for a method for the regeneration of renal stemcells comprising the administration of an effective amount of a substance capable of inducing and/or enhancing Pax2 expression.

L'invention concerne une méthode permettant de traiter, de retarder et/ou de prévenir un dysfonctionnement rénal/une insuffisance rénale chez un mammifère. La méthode comporte l'administration d'une quantité efficace, d'un point de vue thérapeutique, d'une substance capable d'induire et/ou de stimuler l'expression de Pax2. De plus, l'invention concerne l'utilisation d'une dose efficace d'une substance capable d'induire et/ou de stimuler l'expression de Pax2 chez un mammifère, pour préparer une composition pharmaceutique permettant de traiter, de prévenir ou de retarder un dysfonctionnement rénal/une insuffisance rénale chez un mammifère. L'invention concerne en outre un procédé de transformation de tissu mésenchymateux en tissu épithélial, qui comprend l'administration d'une quantité efficace d'une substance capable d'induire et/ou de stimuler l'expression de Pax2 dans le mésenchyme ; et un procédé de régénération de cellules souches rénales, qui comprend l'administration d'une quantité efficace d'une substance capable d'induire et/ou de stimuler l'expression de Pax2.

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