Use of pkc-inhibitors for the manufacture of a medicament...

Details Use of pkc-inhibitors for the manufacture of a medicament... Use of pkc-inhibitors for the manufacture of a medicament...

A - Human Necessities

61

K

A61K 31/40 (2006.01) A61K 31/00 (2006.01)

Patent

CA 2323173

A method for treating asthma and disease conditions associated therewith is disclosed, particularly using the isozyme selective PKC inhibitor, (S)-3,4- [N,N'-1,1'-((2"-ethoxy)-3"'(O)-4"'-(N,N-dimethylamino)-butane)-bis-(3,3'- indoly1)]-1(H)-pyrrole-2,5-dione and its pharmaceutically acceptable salts.

Cette invention se rapporte à un procédé de traitement de l'asthme et des états pathologiques associés à l'asthme, notamment à l'aide de l'inhibiteur de protéine-kinase C (PKC) à sélectivité pour les isozymes, (S)-3,4-[N,N'-1,1'-((2"-éthoxy)-3'''(O)-4'''-(N,N-diméthylamino)-butane)-bis-(3,3'-indolyl)]-1(H)-pyrrole-2,5-dione et ses sels acceptables sur le plan pharmaceutique.

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