A process for the preparation of cyclopropane carboxylic...

C - Chemistry – Metallurgy – 07 – C

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C07C 61/40 (2006.01) C07C 51/09 (2006.01) C07C 62/02 (2006.01) C07D 307/93 (2006.01)

Patent

CA 2224818

The compounds 3-(2,2-dichloro-3,3,3-trifluoro-1-hydroxypropyl)-2,2-dimethyl- (1R,3R)-cyclopropane carboxylic acid, cis-3-(2,2-dichloro-3,3,3-trifluoro-1-hydroxypropyl)-2,2-dimethyl-cyclopropane carboxylic acid and (1R,5S)-4-(1,1-dichloro-2,2,2- trifluoroethyl)-6,6-dimethyl-3-oxabicyclo[3.1.0]hexan-2-one occur as intermediates in a process for the preparation of insecticidally active cyclopropane carboxylate esters, said process starting from 6,6-dimethyl-4- hydroxy-3-oxabicyclo[3.1.0]hexan-2-one (Biocartol) which is reacted with the compound CF3-CC1X2 (X - halogen) in the presence of zinc.

Les composés acide 3-(2,2-dichloro-3,3,3-trifluoro-1-hydroxypropyl)-2,2-diméthyl-(1R,3R)-cyclopropane carboxylique, acide cis-3-(2,2-dichloro-3,3,3-trifluoro-1-hydroxypropyl)-2,2-diméthyl-cyclopropane carboxylique et (1R,5S)-4-(1,1-dichloro-2,2,2-trifluoroéthyl)-6,6-diméthyl-3-oxabicyclo[3.1.0]hexan-2-one constituent des intermédiaires dans un procédé de préparations d'esters de carboxylate de cyclopropane présentant une activité insecticide, ledit procédé commençant à partir de 6,6-diméthyl-4-hydroxy-3-oxabicyclo[3.1.0]hexan-2-one (Biocartol) que l'on fait réagir avec le composé CF>3<-CC1X>2< (X = halogène) en présence de zinc.

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