Immunocytokines with modulated selectivity

Details Immunocytokines with modulated selectivity Immunocytokines with modulated selectivity

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) C07K 1/107 (2006.01) C07K 14/55 (2006.01) C07K 14/76 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/567 (2006.01)

Patent

CA 2469151

The invention provides cytokine fusion proteins, with an increased therapeutic index and methods to increase the therapeutic index of such fusion proteins. The fusion proteins of the invention are able to bind to more than one type of cytokine receptor expressed on cells and also bind to more than one cell type. In addition, the fusion proteins of the invention exhibit a longer circulating half-life in a patient's body than the corresponding naturally occurring cytokine.

L'invention concerne des protéines de fusion de cytokine à indice thérapeutique augmenté et des méthodes permettant d'augmenter l'indice thérapeutique de ces protéines de fusion. Lesdites protéines de fusion peuvent se lier à plus d'un type de récepteur de cytokine exprimé sur des cellules et à plus d'un type de cellule. Elles peuvent également présenter une demi-vie circulante plus longue dans le corps d'un patient que la cytokine naturelle correspondante.

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