Identification of ergothioneine transporter and therapeutic...

Details Identification of ergothioneine transporter and therapeutic... Identification of ergothioneine transporter and therapeutic...

G - Physics

01

N

G01N 33/68 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2568201

The transporter that translocates ergothioneine has been identified. Described are methods for identifying and obtaining compounds capable of modulating ergothioneine transport as well as the use of such compounds for the treatment of diseases ergothioneine may be involved in such as autoimmune diseases, in particular rheumatoid arthritis, as well as other diseases arising from cell damage caused by radiation, radicals and relative oxidant species. Furthermore, diagnostic means and methods for determining the presence or susceptibility to such a disease are provided.

L'invention concerne un transporteur effectuant une translocation d'ergothionéine. Ce transporteur a été identifié dans l'invention. L'invention concerne des méthodes pour identifier et pour obtenir des composés permettant de moduler le transport d'ergothionéine, ainsi que l'utilisation de tels composés pour le traitement de maladies dans lesquelles l'ergothionéine est impliquée, notamment des maladies auto-immunes, en particulier la polyarthrite rhumatoïde, ainsi que d'autres maladies provoquées par des lésions cellulaires causées par des rayonnements, des radicaux et des espèces oxydantes associées. En outre, l'invention concerne un moyen de diagnostic et des méthodes pour déterminer la présence d'une telle maladie ou une prédisposition à une telle maladie.

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