C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/81 (2006.01) C07K 14/395 (2006.01) C12N 1/19 (2006.01) C12N 9/24 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2431013
The invention provides methods and compositions for the highly efficient production of heterologous proteins in yeast and other fungi by overcoming the previous problems associated with failure of these proteins to fold properly. According to the invention, the quality control mechanism employed by fungi which returns misfolded proteins to the cytosol for degradation is manipulated so that these proteins are instead secreted.
L'invention concerne des procédés et des compositions très efficaces permettant d'obtenir des protéines hétérologues dans la levure et d'autres champignons qui visent à surmonter les problèmes de l'art antérieur associés aux défauts de repli correct de ces protéines. Selon l'invention, le mécanisme de contrôle de qualité utilisé par les champignons, qui consiste à renvoyer les protéines repliées de manière inappropriée aux cytosols en vue de leur dégradation, est mis en oeuvre de manière que ces protéines soient sécrétées.
Ng Davis T. W.
Vashist Shilpa
The Penn State Research Foundation
Torys Llp
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