A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/519 (2006.01) A61K 31/7042 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2643056
The invention relates to treating a disease or condition in which it is desirable to inhibit 5'-methylthioadenosine phosphorylase (MTAP) and/or 5'-methylthioadenosine nucleosidase (MTAN). The invention particularly relates to the co-administration of 5'-methylthioadenosine (MTA), or a prodrug of MTA, with one or more MTAP/MTAN inhibitors. Included among the diseases treatable are prostate cancer and head and neck cancer.
La présente invention concerne le traitement d'une maladie ou d'un état pathologique où l'inhibition de la 5'-méthylthioadénosine phosphorylase (MTAP) et/ou de la 5'-méthylthioadénosine nucléosidase (MTAN) est recherchée. La présente invention concerne en particulier la co-administration de la 5'-méthylthioadénosine (MTA), ou d'un promédicament de la MTA, avec un ou plusieurs inhibiteurs de MTAP/MTAN. Les maladies pouvant être traitées incluent le cancer de la prostate et le cancer de la tête et du cou.
Evans Gary Brian
Furneaux Richard Hubert
Schramm Vern L.
Tyler Peter Charles
Albert Einstein College Of Medicine Of Yeshiva University
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Industrial Research Limited
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