Methods for predicting therapeutic response to agents acting...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) A61K 48/00 (2006.01) A61P 5/06 (2006.01) G01N 33/74 (2006.01) C07K 14/61 (2006.01)

Patent

CA 2510045

Methods of producing a subject~s response to an agent capable of binding to a growth hormone receptor (GHR) protein comprise determining in the subject the presence or absence of an allele of the (GHR) gene, wherein the allele is coordinated with the likelihood of having an increased or decreased positive response to the agent, thereby identifying the subject as having an increased or decreased likelihood of responding to treatment with the agent.

L'invention concerne des procédés de production de réponse d'un sujet à un agent capable de se lier à une protéine du récepteur d'hormone de croissance (GHR) consistant à déterminer dans le sujet la présence ou l'absence d'un allèle du gène de GHR, où l'allèle est harmonisé à la probabilité d'avoir une réponse positive accrue ou diminuée avec l'agent, identifiant de ce fait le sujet en tant qu'ayant une probabilité plus grande ou diminuée de réagir au traitement avec l'agent.

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