Isomeric fused pyrrolocarbazoles and isoindolones

Details Isomeric fused pyrrolocarbazoles and isoindolones Isomeric fused pyrrolocarbazoles and isoindolones

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/407 (2006.01) A61K 31/437 (2006.01) A61P 13/08 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 311/00 (2006.01) C07D 333/00 (2006.01) C07D 471/14 (2006.01) C07D 491/14 (2006.01) C07D 495/14 (2006.01)

Patent

CA 2381885

The present invention is directed to novel fused pyrrolocarbazoles and isoindolones, including pharmaceutical compositions, having activity toward trk kinase, platelet derived growth factor receptor (PDGFR) kinase, vascular endothelial growth factor receptor (VEGFR) kinase, NGF-stimulated trk phosphorylation, or tropic factor responsive cells.

La présente invention concerne de nouveaux pyrrolocarbazoles et isoindolones fusionnés ainsi que des compositions pharmaceutiques qui se caractérisent par une activité dirigée contre la kinase de la famille trk, la kinase du récepteur du facteur de croissance dérivé des plaquettes (PDGFR), la kinase du récepteur du facteur de croissance endothéliale vasculaire (VEGFR), la phosphorylation trk stimulée par NGF ou des cellules réagissant au facteur tropique.

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