Phenobarbital derivatives useful in immunoassay

Details Phenobarbital derivatives useful in immunoassay Phenobarbital derivatives useful in immunoassay

C - Chemistry, Metallurgy

07

D

C07D 239/62 (2006.01) G01N 33/94 (2006.01)

Patent

CA 2695460

Phenobarbital derivatives synthesized out of the alkyl chain at the 5-position, particularly with hydrophilic properties, and carrying an active ester at the end, allow formation of aminodextran conjugates that give curves in the desired range of the assay in the ONLINE TDM microparticle assay format when matched against the Roche FPIA antibody specific for phenobarbital ("an antibody specific for phenobarbital").

La présente invention concerne des dérivés du phénobarbital synthétisés à partir de la chaîne alkyle en position 5, en particulier avec des propriétés hydrophiles, et transportant un ester actif à l'extrémité. Ces dérivés permettent la formation de conjugués de l'aminodextrane qui produisent des courbes dans la plage souhaitée du dosage dans le format de dosage des microparticules ONLINE TDM lorsqu'elles sont comparées à l'anticorps Roche FPIA spécifique du phénobarbital ('un anticorps spécifique du phénobarbital').

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