Sulfoalkyl ether cyclodextrin compositions

A - Human Necessities – 61 – K

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A61K 47/40 (2006.01)

Patent

CA 2702603

SAE-CD compositions are provided, along with methods of making and using the same. The SAE-CD composition comprises a sulfoalkyl ether cyclodextrin and less than 100 ppm of a phosphate, wherein the SAE-CD composition has an absorption of less than 0.5 A.U. due to a drug-degrading agent, as determined by UV/vis spectrophotometry at a wavelength of 245 nm to 270 nm for an aqueous solution containing 300 mg of the SAE-CD composition per mL of solution in a cell having a 1 cm path length.

La présente invention concerne des compositions de cyclodextrine à groupements éther sulfoalkylique, ainsi que leurs procédés de fabrication et dutilisation. Les compositions de cyclodextrine à groupements éther sulfoalkylique comprennent une cyclodextrine à groupements éther sulfoalkylique et moins de 100 ppm dun phosphate, la composition de cyclodextrine à groupements éther sulfoalkylique présentant une absorption inférieure à 0,5 A.U. en raison de la présence dun agent de dégradation de médicament, déterminée par spectrophotométrie UV/visible à une longueur donde allant de 245 nm à 270 nm pour une solution aqueuse contenant 300 mg de la composition de cyclodextrine à groupements éther sulfoalkylique par mL de solution dans une cellule ayant une longueur de chemin de 1 cm.

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