Peptides and peptidomimetic compounds affecting the activity...

Details Peptides and peptidomimetic compounds affecting the activity... Peptides and peptidomimetic compounds affecting the activity...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) C07K 7/08 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C07K 14/72 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2205543

This invention relates to peptides and peptidomimetic compounds that modulate the function of G protein-coupled receptors by affecting the ratio of receptor monomer to homooligomeric forms. Novel short peptides of a preferred length of up to about 15 - 20 amino acid residues are modeled on transmembrane domains of G protein-coupled receptors, whose activities are affected by the formation of oligomers. These novel peptides and peptidomimetic compounds can be used to selectively affect the activity of G protein-coupled receptors, thereby functioning as potential therapeutic drugs, etc. A preferred peptide is GIIMGTFTLCWLPFFIVNIV.

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