Novel inhibitors of angiogenesis and tumor growth

Details Novel inhibitors of angiogenesis and tumor growth Novel inhibitors of angiogenesis and tumor growth

C - Chemistry, Metallurgy

07

K

C07K 4/00 (2006.01) A61K 38/02 (2006.01) A61K 38/03 (2006.01) A61K 38/16 (2006.01) C07K 4/12 (2006.01) C07K 14/00 (2006.01) C07K 14/435 (2006.01) C07K 14/475 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2337438

This invention provides for polypeptides that have surprising anti-angiogenic activity. These peptides are derived from Saposin B, a previously known protein involved in the hydrolysis of sphingolipids. In addition, methods of treating mammals with these anti-angiogenic polypeptides are provided, as well as the pharmaceutical compositions used to treat. Furthermore, the polypeptides of this invention can be used in fusion proteins, wherein the fusion proteins also comprise cell targeting or cytotoxic moieties. Also provided is the receptor to which these polypeptides bind.

Cette invention concerne des polypeptides qui possèdent une surprenante activité angiogénique. Ces peptides sont dérivés de la Saposine B qui est une protéine connue impliquée dans l'hydrolyse des sphingolipides. On décrit des procédés de traitement destinés à des mammifères dans lesquels on utilise ces polypeptides anti-angiogéniques, ainsi que des compositions pharmaceutiques utilisées pour le traitement. En outre, les polypeptides de cette invention peuvent être utilisés dans des protéines hybrides qui comprennent elles-mêmes des fractions de ciblage de cellule ou des fractions cytotoxiques. Le récepteur auquel se lient ces polypeptides est également décrit.

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