Tetralin analogs having sphingosine 1-phosphate agonist...

C - Chemistry – Metallurgy – 07 – D

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C07D 271/06 (2006.01) A61K 31/137 (2006.01) A61K 31/381 (2006.01) A61K 31/4245 (2006.01) A61P 19/00 (2006.01) C07C 215/38 (2006.01) C07D 233/16 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2669102

Tetralin analogs that have agonist activity at one or more of the SlP receptors are provided. The compounds are sphingosine analogs, which, after phosphorylation, can behave as agonists at SlP receptors.

La présente invention concerne des analogues de tétraline ayant une activité agoniste à un ou plusieurs récepteurs S1P. Les composés sont des analogues de sphingosine, qui, après phosphorylation, peuvent se comporter comme agonistes de récepteurs S1P.

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