Rotamase enzyme activity inhibitors

Details Rotamase enzyme activity inhibitors Rotamase enzyme activity inhibitors

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 31/44 (2006.01) A61K 31/444 (2006.01) A61K 38/18 (2006.01)

Patent

CA 2236328

This invention relates to the method of using specially formulated neurotrophic pipecolic acid derivative compounds having an affinity for FKBP- type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.

Cette invention concerne le procédé d'utilisation de composés de dérivé d'acide pipécolique neurotrophique spécifiquement formulés qui présentent une affinité pour les immunophilines du type FKBP en tant qu'inhibiteurs de l'activité enzymatique associée à des protéines d'immunophilines, et plus particulièrement comme inhibiteurs de l'activité enzymatique de peptidyl-prolyle isomérase ou rotamase pour stimuler ou favoriser la croissance ou la régénération neuronale.

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