C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 35/12 (2006.01) A61K 35/14 (2006.01) A61K 38/16 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 14/415 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 15/13 (2006.01) C12N 15/29 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2222247
The present invention relates to compositions and methods for treating diseases of the immune system. More particularly, the invention relates to an immunotoxin molecule comprising an antibody specific for human CD80 or CD86 antigen located on the surface of a human cell, coupled to a toxin molecule or active fragment thereof, wherein the binding of the immunotoxin to the CD80 or CD86 antigen results in the killing of the CD80 or CD86 expressing cell. In particular, this invention relates to methods of preventing allograft rejection and methods for treating autoimmune diseases and various malignancies of lymphoid origin.
La présente invention concerne des compositions et des méthodes pour traiter des maladies du système immunitaire. Plus particulièrement, l'invention concerne une molécule d'immunotoxine comprenant un anticorps spécifique de l'antigène humain CD80 et CD86 se trouvant sur la surface d'une cellule humaine, cet anticorps étant couplé à une molécule de toxine ou à un fragment actif de celle-ci. La fixation de l'immunotoxine sur l'antigène CD80 ou CD86 provoque la mort de la cellule exprimant CD80 ou CD86. Egalement, cette invention concerne des méthodes pour empêcher le rejet d'allogreffes et des méthodes pour traiter des maladies auto-immunes et différentes tumeurs malignes d'origine lymphoïde.
de Boer Mark
de Gast G. C.
Innogenetics N.v.
Smart & Biggar
LandOfFree
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