C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2669260
Methods of inhibiting pathological angiogenesis in a subject are disclosed. In particular examples, the method includes administering a therapeutically effective amount of a composition to a subject wherein the composition includes a specific binding agent that preferentially binds to one or more pathological angiogenesis marker proteins including Vscp, CD276, ETSvg4 (Pea3), CD137(4-1BB), MiRP2, Ubiquitin D (Fat 10), Doppel (prion-PLP), Apelin, Plgf, Ptprn (IA-2), CD109, Ankylosis, and collagen VIII.alpha.1. In additional examples, methods to deliver a therapeutic agent to a brain or liver endothelial cell are also disclosed.
L'invention concerne des procédés d'inhibition d'une angiogénèse pathologique chez un sujet. Dans des exemples particuliers, le procédé comprend l'administration d'une quantité thérapeutiquement efficace d'une composition à un sujet, la composition comprenant un agent de liaison spécifique qui se lie de préférence à une ou plusieurs protéines marqueurs de l'angiogenèse pathologique comprenant Vscp, CD276, ETSvg4 (Pea3), CD137(4-1BB), MiRP2, ubiquitine D (Fat 10), Doppel (prion-PLP), apéline, Plgf, Ptprn (IA-2), CD109, ankylose et collagène VIII.alpha.1. Dans des exemples supplémentaires, des procédés de distribution d'un agent thérapeutique à une cellule endothéliale cérébrale ou hépatique sont également présentés.
Seaman Steven
St Croix Brad
Smart & Biggar
The Government Of The United States Of America As Represented By
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