C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2279260
The present invention provides a novel human apoptosis-associated protein (NHAAP) and polynucleotides which identify and encode NHAAP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NHAAP and a method for producing NHAAP. The invention also provides for agonists, antibodies, or antogonists specifically binding NHAAP, and their use, in the prevention and treatment of diseases associated with expression of NHAAP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NHAAP for the treatment of diseases associated with the expression of NHAAP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NHAAP.
La présente invention concerne une nouvelle protéine humaine associée à l'apoptose (NHAAP) et des polynucléotides identifiant et codant ladite NHAAP. Elle concerne également des vecteurs d'expression et des cellules hôtes obtenus par génie génétique comprenant des séquences nucléotidiques codant la NHAAP, ainsi qu'un procédé de production de la NHAAP. L'invention a aussi pour objet des agonistes, des anticorps, ou des antagonistes se liant spécifiquement à la NHAAP, et leur utilisation pour la prévention et le traitement de maladies associées à l'expression de la NHAAP. L'invention porte, en outre, sur l'utilisation de molécules antisens de polynucléotides codant la NHAAP pour le traitement de maladies associées à l'expression de la NHAAP. Enfin, l'invention concerne des méthodes diagnostiques faisant intervenir ledit polynucléotide, ou des fragments ou le complément de ce polynucléotide, et des anticorps se liant spécifiquement à la NHAAP.
Goli Surya K.
Hillman Jennifer L.
Incyte Genomics Inc.
Incyte Pharmaceuticals Inc.
Smart & Biggar
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