Styelins

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A01N 63/02 (2006.01) A23L 3/3544 (2006.01) A61K 38/17 (2006.01) A61L 2/16 (2006.01) C07K 14/435 (2006.01) C07K 16/18 (2006.01) A61K 7/00 (1995.01)

Patent

CA 2228730

Novel microbial peptides called styelins are of the formula J1-X2-X3-B'4-B"5-J6-X'7-B8-J9-X10 J11-Z12-X13-J*14-B*15-B16-B18-O19-J*20 X21-B22-J23-J24-X'25-C26-X*27-J28-X29-Z30 and the pharmaceutically acceptable acetylated forms and salts amides and esters thereof wherein: B represents a basic amino acid; B' represents a basic or a small amino acid; B" represents a basic amino acid or proline; B* represents a basic amino acid or tyrosine, wherein said tyrosine optionally is alkylated; X represents a hydrophobic amino acid; X' represents a hydrophobic or a small amino acid; Z represents a basic or a hydrophobic amino acid; J represents a small amino acid; J* represents a small amino acid or tyrosine which tyrosine is optionally methylated; O represents an amino acid containing a hydroxyl group; and C represents any amino acid.

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