Pyridyl ethers and thioethers as ligands for nicotinic...

Details Pyridyl ethers and thioethers as ligands for nicotinic... Pyridyl ethers and thioethers as ligands for nicotinic...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4427 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2341989

The present invention provides compounds of formula (I) wherein m is 0, 1 or 2; p is 0 or 1; Y is O, S, S(O) or S(O)2 and R1 to R7 are various substituents as selective modulators of the nicotinic acetylcholine receptor useful in the treatment of pain, Alzheimer's disease, memory loss or dementia or loss of motor function.

L'invention concerne des composés représentés par la formule (I). Dans ladite formule, m vaut 0, 1 ou 2; p vaut 0 ou 1; Y est O, S(O) ou S(O)¿2? et R?1¿ à R?7¿ sont des substituants divers. Ces composés, qui tiennent lieu de modulateurs sélectifs du récepteur de l'acétylcholine nicotinique, sont utiles dans le traitement de la douleur, de la maladie d'Alzheimer, de l'amnésie ou de la démence ou bien encore de la perte de fonction motrice.

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