C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A61K 38/48 (2006.01) C07K 16/40 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2211541
Substantially pure interleukin-1 converting enzyme isoforms are disclosed. Pharmaceutical compositions comprising one or more interleukin-1 converting enzyme isoforms are disclosed. Nucleic acid molecules that encode interleukin- 1 converting enzyme isoforms, recombinant expression vectors that comprise a nucleic acid sequence that encodes an interleukin-1 converting enzyme isoform, and host cells that comprise recombinant expression vectors that comprise nucleic acid sequences that encode interleukin-1 converting enzyme isoforms are disclosed. Fragments of nucleic acid molecules with sequences encoding interleukin-1 converting enzyme isoform and oligonucleotide molecules that comprise a nucleotide sequence complimentary to fragment of a nucleotide sequence that encodes an interleukin-1 converting enzyme isoform are disclosed. Antibodies which bind to an epitope on interleukin-1 converting enzyme isoforms are disclosed. Methods of identifying inhibitors of ICE isoforms are disclosed.
L'invention concerne des isoformes sensiblement pures de l'enzyme de conversion de l'interleukine-1, des compositions pharmaceutiques contenant une ou plusieurs isoformes de l'enzyme de conversion de l'interleukine-1, des molécules d'acide nucléique qui codent les isoformes de l'enzyme de conversion de l'interleukine-1, des vecteurs d'expression de recombinaison qui comprennent une séquence d'acide nucléique qui code une isoforme de l'enzyme de conversion de l'interleukine-1, des cellules hôtes qui comprennent des vecteurs d'expression de recombinaison contenant des séquences d'acide nucléique qui codent des isoformes de l'enzyme de conversion l'interleukine-1, des fragments de molécules d'acide nucléique contenant des séquences qui codent une isoforme de l'enzyme de conversion de l'interleukine-1 et des molécules oligonucléotidiques qui comprennent une séquence nucléotidique complémentaire du fragment d'une séquence nucléotidique qui code une isoforme de l'enzyme de conversion de l'interleukine-1, des anticorps qui se fixent à un épitope de l'enzyme de conversion de l'interleukine-1 et des procédés pour identifier des inhibiteurs des isoformes en question.
Alnemri Emad S.
Fernandez-Alnemri Teresa
Litwack Gerald
Borden Ladner Gervais Llp
Thomas Jefferson University
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