Retroviral vectors capable of expressing multimeric proteins...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/86 (2006.01) A61K 35/12 (2006.01) A61K 48/00 (2006.01) C07K 14/74 (2006.01) C12N 5/10 (2006.01) C12N 15/79 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2162056

This invention relates to retroviral vectors that express multiple polypeptide subunits of a eukaryotic protein from a single polycistronic mRNA and the proteins produced from these vectors. The expressed proteins are particularly useful for inducing transportation tolerance and the vectors are useful as agents for mediating gene transfer into eukaryotic cells.

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