Use of sodium channel blockers for the treatment of visceral...

Details Use of sodium channel blockers for the treatment of visceral... Use of sodium channel blockers for the treatment of visceral...

A - Human Necessities

61

K

A61K 31/7064 (2006.01) A61K 31/519 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2619856

The invention provides methods for treating visceral pain and pain associated with therapy. The compounds useful in the methods of the invention are blockers of sodium ion channels, and in particular compounds that bind to the SSl or SS2 extracellular mouth of the .alpha.-subunit thereof. Particularly useful compounds are saxitoxin and its derivatives and analogues and tetrodotoxin and its derivatives and analogues.

L'invention concerne des procédés pour traiter les douleurs viscérales, et les douleurs liées à un traitement. Les composés utilisés dans ces procédés sont des bloqueurs des canaux sodiques, et en particulier des composés qui se lient à la bouche extracellulaire SS1 ou SS2 de la sous-unité alpha correspondante. De manière spécifique, ces composés sont la saxitoxine et ses dérivés et analogues, ainsi que la tétrodotoxine et ses dérivés et analogues.

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