Polynucleotide encoding a novel human growth factor with...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 14/475 (2006.01) C07K 14/485 (2006.01) C07K 16/22 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2450127

The present invention provides novel polynucleotides encoding BGS-8 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-8 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

La présente invention concerne des nouveaux polynucléotides codant pour les polypeptides BGS-8, ainsi que leurs fragments ou homologues. L'invention concerne également des vecteurs, des cellules hôtes, des anticorps et des méthodes de recombinaison et de synthèse destinées à la production de ces polypeptides. L'invention concerne également des méthodes diagnostiques et thérapeutiques utilisant ces nouveaux polypeptides BGS-8 pour diagnostiquer, traiter et/ou prévenir différentes pathologies et/ou troubles associés à ces polypeptides. L'invention concerne également des méthodes de criblage permettant d'identifier des agonistes et des antagonistes des polynucléotides et polypeptides de la présente invention.

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