Tumor-specific antibodies and antigen

Details Tumor-specific antibodies and antigen Tumor-specific antibodies and antigen

C - Chemistry, Metallurgy

12

N

C12N 5/18 (2006.01) A61K 47/48 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2144750

The invention relates to a novel epitope of 180,000 daltons for the NCAM antigen and a monoclonal antibody, SEN7, di- rected against this antigen, and their use in diagnosis and therapy of small-cell carcinoma of the lung. The antibody SEN7 reacts significantly more selectively than previously known antibodies with cells of small-cell carcinoma of the lung, and binds with high avidity. In particular, no reaction occurs with leucocytes or healthy kidney or lung epithelial cells. The novel antigen is domi- nantly expressed by cells of small-cell carcinoma of the lung with a high copy number.

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