C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12Q 1/70 (2006.01)
Patent
CA 2134113
Method of destabilization of the secondary intrastrand structure of a simple strand polynucleotide, and capture of said polynucleotide. The method is characterized in that a device comprising an oligonucleotide attached to a support is placed in contact with a liquid phase containing said polynucleotide, at a temperature of below 50 DEG C, said oligonucleotide acting as a capture probe and containing a destabilizing sequence capable of hydridizing with a non self-complementary sequence involved in the polynucleotide's secondary structure. The invention also concerns a device for carrying out said method.
2134113 9419490 PCTABS00167 Procédé de déstabilisation d'une structure secondaire intracaténaire d'un polynucléotide simple brin, et de capture dudit polynucléotide, caractérisé par le fait que l'on met en contact un dispositif comprenant un oligonucléotide fixé sur un support avec une phase liquide contenant ledit polynucléotide, à une température inférieure à 50 ·C, ledit oligonucléotide jouant le rôle de sonde de capture et contenant une séquence dite déstabilisante capable de s'hybrider avec une séquence non auto-complémentaire participant à ladite structure secondaire dudit polynucléotide; et dispositif pour la mise en oeuvre de ce procédé.
Christen Richard
Mabilat Claude
Bio Merieux
Robic
LandOfFree
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