Human kdel receptor

Details Human kdel receptor Human kdel receptor

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/10 (2006.01) C12N 15/85 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2270407

The present invention provides a novel human KDEL receptor (NHKR) and polynucleotides which identify and encode NHKR. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NHKR and a method for producing NHKR. The invention also provides for agonists, antibodies, or antagonists specifically binding NHKR, and their use, in the prevention and treatment of diseases associated with expression of NHKR. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NHKR for the treatment of diseases associated with the expression of NHKR. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NHKR.

Cette invention concerne un nouveau récepteur KDEL humain (NHKR) et des polynucléotides qui identifient et codent NHKR; des vecteurs d'expression produits par génie génétique et des cellules hôtes comprenant les séquences d'acides nucléiques codant NHKR, et un procédé de production de NHKR. Cette invention concerne également des agonistes, des anticorps ou des antagonistes se liant spécifiquement à NHKR et leur utilisation dans la prévention et le traitement de maladies associées à l'expression de NHKR; l'utilisation de molécules non codantes contre des polynucléotides codant NHKR pour traiter des maladies associées à l'expression de NHKR; et des déterminations de diagnostic dans lesquels on utilise le polynucléotide ou des fragments ou le complément de ce dernier ainsi que des anticorps se liant spécifiquement à NHKR.

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