Recombinant adenovirus comprising a chimeric penton base...

Details Recombinant adenovirus comprising a chimeric penton base... Recombinant adenovirus comprising a chimeric penton base...

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) A61K 48/00 (2006.01) C07K 14/075 (2006.01) C07K 14/705 (2006.01) C07K 19/00 (2006.01) C12N 7/00 (2006.01) C12N 15/62 (2006.01) C12N 15/86 (2006.01) C12N 15/861 (2006.01) C12N 15/866 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2198861

A recombinant adenovirus comprising a chimeric penton base protein, which includes a nonpenton base sequence, and a therapeutic gene, a method of gene therapy involving the use of such adenovirus, and adenoviral transfer vectors for the generation of such recombinant adenovirus are provided.

Cette invention concerne un adénovirus de recombinaison comprenant une protéine à base pentonique chimérique qui inclut une séquence de base non pentonique, et un gène thérapeutique, un procédé de thérapie génique impliquant l'utilisation de cet adénovirus, ainsi que des vecteurs de transfert d'adénovirus utilisés pour produire cet adénovirus de recombinaison.

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