Cloning of the biosynthetic pathway genes for...

Details Cloning of the biosynthetic pathway genes for... Cloning of the biosynthetic pathway genes for...

C - Chemistry, Metallurgy

12

N

C12N 15/52 (2006.01) C12N 15/76 (2006.01) C12P 29/00 (2006.01) C12Q 1/18 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2047833

The present invention relates to the cloning, isolation and DNA (isolated fragment from Streptomyces aureofaciens) which directs the synthesis of tetracycline and chlortetracycline, in a heterologous host such as Streptomyces lividans. The claimed plasmids are isolated by screening a cosmid library, constructed in Escherichia coli, for the expression of tetracycline resistance in S. lividans.

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