Method for producing cyclic lactams

C - Chemistry – Metallurgy – 07 – D

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C07D 201/08 (2006.01)

Patent

CA 2288336

The invention relates to a method for producing cyclic lactams of formula (I), in which R1 stands for a hydrogen atom, an alkyl, a cycloalkyl or an aryl; A stands for a C3-C12-alkylene radical, which can be substituted by 1, 2, 3, 4, 5 or 6 substituents, selected independently from each other from the alkyl, cycloalkyl or aryl groups. In this method, a .omega.-amino carbonic acid nitrile of formula (II) HR1N - A - CN, in which R1 and A have the meaning given above, is reacted in the presence of at least one catalyst. The method is characterized in that nitrile II is converted into an oligomer mixture and then treated with overheated water vapour.

Procédé de fabrication de lactames cycliques de formule (I), dans laquelle R?1¿ désigne un atome d'hydrogène, un alkyle, cycloalkyle ou aryle; A désigne un reste alkylène en C¿3?-C¿12? pouvant être substitué par 1, 2, 3, 4, 5 ou 6 substituants choisis, indépendamment les uns des autres, parmi les groupes alkyle, cycloalkyle ou aryle, consistant à faire réagir un nitrile d'acide .omega.-aminocarboxylique de formule (II) HR?1¿N - A - CN, dans laquelle R?1¿ et A ont les désignations précitées, en présence d'au moins un catalyseur, caractérisé en ce qu'on transforme le nitrile (II) en un mélange oligomère, et en ce qu'on traite ensuite le produit obtenu par de la vapeur d'eau surchauffée.

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