Vascular endothelial growth factor 2

A - Human Necessities – 61 – K

Patent

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A61K 48/00 (2006.01) C07K 14/52 (2006.01)

Patent

CA 2386103

Disclosed are human VEGF-2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA (RNA) encoding such VEGF-2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides and polynucleotides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.

Cette invention a trait à des polypeptides du VEGF-2, à des fragments, des analogues ou des dérivés de ceux-ci, biologiquement actifs et des plus utiles en matière de diagnostic ou de thérapie, ainsi qu'à de l'ADN (ARN) codant ces polypeptides du VEGF-2. L'invention porte également sur des procédés de production de ces polypeptides, utilisant des techniques de recombinaison, ainsi que sur des anticorps et des antagonistes de ceux-ci. Ces polypeptides et polynucléotides peuvent avoir une utilisation thérapeutique, en l'occurrence pour stimuler la cicatrisation d'une blessure ainsi que pour réparer un tissu vasculaire. Cette invention concerne, de surcroît, l'utilisation qui est faite des anticorps et des antagonistes susmentionnés pour inhiber une angiogenèse tumorale et, partant, une croissance tumorale, ainsi que pour traiter l'inflammation, la rétinopathie diabétique, la polyarthrite rhumatoïde et le psoriasis.

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