Controlled production and delivery of biologically active...

Details Controlled production and delivery of biologically active... Controlled production and delivery of biologically active...

C - Chemistry, Metallurgy

12

N

C12N 15/74 (2006.01) A61K 35/74 (2006.01) A61K 38/17 (2006.01) C12N 1/21 (2006.01)

Patent

CA 2640343

The invention provides gut commensal bacteria that have been modified to express one or more biologically active polypeptides or protiens, the bacteria includes a promoter, such as a xylanase promoter, which is induced in response to the presence of xylan in the diet and which regulates the expression of the biologically active polypeptide or protien.

L'invention concerne une bactérie intestinale commensale qui a été modifiée afin d'exprimer une ou des protéine(s) ou un ou des polypeptide(s) biologiquement actif(s). Ladite bactérie comprend un promoteur, tel qu'un promoteur de la xylanase, induit en réponse à la présence d'une xylane dans un régime alimentaire et régulant l'expression du polypeptide ou de la protéine biologiquement actif.

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