Compositions and methods for producing a composition

Details Compositions and methods for producing a composition Compositions and methods for producing a composition

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) A61K 38/17 (2006.01) C07K 1/16 (2006.01)

Patent

CA 2634760

The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass- producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.

L'invention concerne des cellules de mammifères capables de produire du CTLA4-Ig recombinant et des variants de celui-ci. L'invention concerne également des compositions comprenant du CTLA4-Ig et leurs formulations. L'invention concerne en outre des procédés de production en gros volume de CTLA4-Ig à partir de cellules de mammifères capables de produire cette protéine recombinante, ainsi que des procédés de purification du CTLA4-Ig.

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