Antibody formulations

Details Antibody formulations Antibody formulations

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2692681

This invention relates to a shear and temperature stable antibody formulations that are more stable than compared to a standard formulation (such as 30 mM citrate, 10OmM NaCl, pH 6.5). The present invention's shear and temperature stable antibody formulations show reduced precipitation when subjected to stress conditions but the standard formulation had aggregated. This result was unpredictable because thermodynamically the two formulations are similar as seen by their DSC (differential scanning calorimeter) profiles.

L'invention concerne des formulations d'anticorps stables au cisaillement et à la température, qui sont plus stables qu'une formulation type (telle que citrate à 30 mM, NaCl à 100 mM, pH 6,5). Les formulations d'anticorps stables au cisaillement et à la température de la présente invention affichent une précipitation réduite lorsqu'elles sont soumises à des conditions de contrainte, contrairement à la formulation type qui s'agrège. Ce résultat était imprévisible du fait que les deux formulations sont thermodynamiquement similaires, comme qu'observé par leurs profils DSC (calorimètre à balayage différentiel).

Affiliated with

Also associated with

Rating

Antibody formulations does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibody formulations, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibody formulations will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1452447