Thieno'2,3-d pyrimidindione derivatives as matrix...

Details Thieno'2,3-d pyrimidindione derivatives as matrix... Thieno'2,3-d pyrimidindione derivatives as matrix...

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/505 (2006.01) A61K 31/519 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2433778

Selective MMP-13 inhibitors are fused pyrimidinones of the formula or a pharmaceutically acceptable salt thereof, wherein: W, together with the carbon atoms to which it is attached, form a 5-membered ring diradical Y is O, S, SO, SO2, NR5, or CH2, A is-C-or S-; B is O or NR5; or A and B are taken together to form -C.ident.C-; R1, R4, and R5 are hydrogen, alkyl, alkenyl, alkynyl, (CH2)n aryl, (CH2)n cycloalkyl, C1 C6 alkanoyl, or (CH2)n heteroaryl; R2 and R3 are hydrogen, alkyl, alkenyl, alkynyl CN, NO2, NR4R5, (CH2)n cycloalkyl, (CH2)n aryl, or (CH2)n heteroaryl; R2 may further be halo; n is an integer of from 0 to 5; and R4 and R5 when taken together with the nitrogen to which they are attached complete a 3-to 8-membered ring containing carbon atoms and optionally containing O, S, or N, and substituted or unsubstituted; with the proviso that R1 and R3 are not both selected from hydrogen and C1-C6 alkyl.

La présente invention concerne des inhibiteurs sélectifs de la MMP-13, qui sont des pyrimidinones fusionnées de la formule (1) ou un sel pharmaceutiquement acceptable de ces derniers, dans laquelle : W, avec les atomes de carbone auxquels il est attaché, forme un noyau à 5 chaînons et à deux radicaux, Y est O, S, SO, SO¿2?, NR?5¿, ou CH¿2?, A est-C-ou S-; B est O ou NR?5¿; ou A et B sont mis ensemble pour former -C.ident.C-; R?1¿, R?4¿, et R?5¿ sont hydrogène, alkyle, alcényle, alkynyle, (CH¿2?)¿n? aryle, (CH¿2?)¿n? cycloalkyle, C¿1-?C¿6? alkanoyle, ou (CH¿2?)¿n? hétéroaryle; R?2¿ et R?3¿ sont hydrogène, alkyle, alcényle, alkynyle CN, NO¿2?, NR?4¿R?5¿, (CH¿2?)¿n? cycloalkyle, (CH¿2?)¿n? aryle, ou (CH¿2?)¿n? hétéroaryle; R?2¿ peut en outre être halo; n est un entier de 0 à 5; et R?4¿ et R?5¿, lorsqu'ils sont pris ensemble avec l'azote aquel ils sont attachés, forment un noyau de 3 à 6 chaînons renfermant des atomes de carbone et renfermant facultativement O, S, ou N, et sont substitués ou non substitués ; à condition que R?1¿ et R?3¿ soient tous deux choisis entre hydrogène et C¿1?-C¿6? alkyle.

Affiliated with

Also associated with

Rating

Thieno'2,3-d pyrimidindione derivatives as matrix... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Thieno'2,3-d pyrimidindione derivatives as matrix..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thieno'2,3-d pyrimidindione derivatives as matrix... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1452705