A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/58 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/50 (2006.01) A61P 25/00 (2006.01) A61P 25/24 (2006.01) A61P 25/32 (2006.01)
Patent
CA 2611430
The present invention relates to pharmaceutical compositions of the neuroactive steroid 3.alpha.-hydroxy-3.beta.-methoxymethyl-21-(1.prime.- imidazolyl)-5.alpha.-pregnan-20-one or a pharmaceutically-acceptable salt or solvate thereof., with properties desirable for use in treating mood disorders and the like. The pharmaceutical compositions provide sustained therapeutic plasma levels of 3.alpha.-hydroxy- 3.beta.-methoxymethyl-21-(1.prime.- imidazolyl)-5.alpha.-pregnan-20-one. The present invention also relates to methods of treating these disorders by administering the pharmaceutical compositions.
L'invention concerne des compositions pharmaceutiques à base du stéroïde neuroactif 3a-hydroxy-3ß-méthoxyméthyl-21-(1'-imidazolyl)-5a-pregnan- 20-one ou d'un de ses sels/solvats pharmaceutiquement acceptables, et qui présentent des caractéristiques souhaitables permettant leur utilisation dans le traitement des troubles de l'humeur et similaires. Les compositions pharmaceutiques possèdent des niveaux de plasma thérapeutiques stables de 3a-hydroxy-3ß-méthoxyméthyl-21-(1'-imidazolyl)-5a-pregnan-20-one. L'invention concerne également des méthodes de traitement de ces troubles par l'administration desdites compositions pharmaceutiques.
Euro-Celtique S.a.
Gowling Lafleur Henderson Llp
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