Pyrimidine derivatives which are angiotensin ii receptor...

Details Pyrimidine derivatives which are angiotensin ii receptor... Pyrimidine derivatives which are angiotensin ii receptor...

C - Chemistry, Metallurgy

07

D

C07D 403/10 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 239/30 (2006.01) C07D 239/34 (2006.01) C07D 239/36 (2006.01) C07D 239/38 (2006.01) C07D 239/40 (2006.01) C07D 239/42 (2006.01) C07D 239/56 (2006.01) C07D 239/58 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/00 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/00 (2006.01) C07D 409/10 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2045327

IN THE UNITED STATES PATENT AND TRADEMARK OFFICE PATENT APPLICATION entitled: Novel pyrimidine derivatives which are angio- tensin II receptor antagonists, their methods of preparation and pharmaceutical composi- tions in which they are present in the names of: Nicole BRU-MAGNIEZ Jean-Marie TEULON Eric NICOLAI Assignee: Laboratoires UPSA ABSTRACT OF THE DISCLOSURE The present invention relates to the deriva- tives of the formulae Image Image Formula (I) Formula (I') in which: R1 is a lower alkyl radical having 1 to 6 carbon atoms or a lower alkylene radical having 2 to 6 carbon atoms, R2 is a lower alkyl radical, an aromatic, a functional group, the hydrogen atom or a halogen atom, X can be a bond, an oxygen or sulfur atom, a radical NH or a halogen, R3 or R'3 can be a functional group, a hydrogen atom, a lower alkyl radical, an aromatic ring or a heterocycle, and R4 can be a 2-sulfobenzoylamino, 2-carboxy-3,6- dichlorobenzoylamino, 2-carboxyphenyl, 2-sulfoxyphenyl or 2-(tetrazol-5-yl)phenyl group, and their addition salts, and to their use in thera- peutics, especially for the treatment of cardiovascular diseases and in particular for the treatment of hyper- tension and cardiac insufficiency.

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