Formulations of pyridoxal -5'-phosphate and methods of...

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A61K 31/675 (2006.01) A61K 9/28 (2006.01) A61K 9/48 (2006.01) A61K 47/02 (2006.01) A61K 47/12 (2006.01) A61K 47/30 (2006.01) A61K 47/38 (2006.01)

Patent

CA 2589200

The present invention provides pharmaceutical compositions for oral administration comprising pyridoxal-5'-phosphate wherein the compositions contain an amount of pyridoxal-5-phosphate of at least 50% w/w and methods of preparing the pharmaceutical compositions. The present invention also provides a pre-blend for the manufacture of a pyridoxal 5'-phosphate oral dosage form comprising pyridoxal 5'-phosphate and microcrystalline cellulose, wherein the pre-blend contains an amount pyridoxal-5-phosphate greater than or equal to 80% w/w.

L'invention concerne des compositions pharmaceutiques pour administration orale, qui renferment du pyridoxal-5'-phosphate en quantité d'au moins 50 % (poids/poids), et des procédés d'élaboration correspondants. On décrit aussi un pré-mélange pour l'élaboration de forme pharmaceutique orale de pyridoxal 5'-phosphate renfermant à la fois du pyridoxal 5'-phosphate et de la cellulose microcristaline, sachant que le pré-mélange contient une quantité de pyridoxal-5-phosphate supérieure ou égale à 80 % (poids/poids).

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